Senisik, A. M.Ichedef, C.Kilcar, A. Y.Ucar, E.Ari, K.Goksoy, D.Parlak, Y.Bilgin, Bedriye Elvan SayitTeksoz, S.2019-10-272019-10-2720180236-57311588-27800236-57311588-2780https://doi.org/10.1007/s10967-018-5772-xhttps://hdl.handle.net/11454/30441This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [F-18]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 A degrees C for 30 min in a vial containing AO-GlyGly and [F-18]FDG solution. The radiolabeled product ([F-18]FDG-GlyGly) was obtained with 98.65 +/- 0.35% yield without any purification step which makes this method more attractive for F-18 radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [F-18]FDG tagged GlyGly in vivo.en10.1007/s10967-018-5772-xinfo:eu-repo/semantics/closedAccessFDGImagingGlycylglycinePETRadiopharmaceuticalsArticle3162457463WOS:000431040600006Q3