Akturk, MerveKarabiberoglu, Sukriye UlubayDursun, Zekerya2019-10-272019-10-2720181040-03971521-41091040-03971521-4109https://doi.org/10.1002/elan.201700590https://hdl.handle.net/11454/30726A copper nano particles and cerium (IV) oxide modified carbon nanotube based composite on glassy carbon electrode (Cu-CeO2/MWCNT/GCE) was fabricated for simultaneous determination of guanine and adenine. The surface morphology, chemistry and conductance of the prepared electrodes were characterized by scanning electron microscopy (SEM), energy dispersion X-ray (EDX), X-Ray photoelectron spectroscopy (XPS) and electrochemical impedance spectroscopy (EIS). The Cu-CeO2/MWCNT/GCE improved electrochemical behaviour of guanine and adenine compared to other electrodes. The modified electrode was also used for individual and simultaneous determination of guanine and adenine. Under optimized conditions, the calibration curves were obtained linearly in the range of 0.20 to 6.00M for the guanine and 0.10 to 8.0M for the adenine by differential pulse voltammetry. The limits of detection of guanine and adenine were calculated as 0.128 and 0.062M, respectively. Interferences studies were also performed in the presence of inorganic and organic compounds. Moreover, the determination of guanine and adenine contents were carried out in a calf thymus DNA sample by the developed method with satisfactory results.en10.1002/elan.201700590info:eu-repo/semantics/closedAccessmetal nanoparticlemetal oxidemultiwall carbon nanotubesadenineguanineArticle302238249WOS:000424874800007Q2Q2