Altuncı, Yusuf AliYalçınlı, SercanEfe, Mehmet2023-01-122023-01-1220202651-4311https://search.trdizin.gov.tr/yayin/detay/496378https://hdl.handle.net/11454/81464Aim Clinical symptoms of adrenal insufficiency are nonspecific and thus misdiagnosis is common. Hyperpigmentation is a specific finding for the diagnosis of primary adrenal insufficiency. This case report is presented to emphasize the importance of the presence of hyperpigmentation in the definition of primary adrenal insufficiency.CaseA 66-year-old male with no previous history of disease presented to our emergency department with complaints of weakness, nausea, and vomiting. On his initial evaluation, blood pressure was 71/55 mmHg. Physical examination revealed darkening of skin color and increased pigmentation on hands and tongue. There were no other significant findings on physical examination. The laboratory findings of the patient were: Adrenocorticotropic hormone (ACTH)>1250 pg/mL (reference value: <46), cortisol 0.54 ?g/dL (reference value: 4.82-19.5). The patient was hospitalized with the diagnosis of primary adrenal insufficiency.ConclusionIn cases where hyperpigmentation, nausea, vomiting, and weakness accompanying unexplained hypotension, the diagnosis of primary adrenal insufficiency should be kept in mind.eninfo:eu-repo/semantics/openAccesshyperpigmentationhypotensionAdrenal insufficiencyArticle311820496378