Yilmaz, SanemSimsek, ErdemTekin, Hande GazeteciAktan, GulGokben, SarenurTekgul, Hasan2023-01-122023-01-1220220736-02581537-1603https://doi.org/10.1097/WNP.0000000000000829https://hdl.handle.net/11454/77422Purpose: To compare the effects of chloral hydrate and melatonin on sleep EEG recordings in children by using standard EEG sleep stages and the bispectral index scores (BIS). Methods: A total of 86 children were randomly assigned to two groups: (1) melatonin group (n = 43) and (2) chloral hydrate group (n = 43). BIS monitoring scores and sleep EEGs were recorded simultaneously. The effect of two drugs on sleep EEG recording was evaluated with sleep stages of EEG and BIS. Results: There was no statistically significant difference between the groups with regard to time to sleep onset and the need for a second drug (P = 0.432; P = 1.000). Eight patients (18.6%) in chloral hydrate group reported side effects while there were no reported side effects in the melatonin group (P = 0.006). Mean BIS values during EEG recordings were similar in both groups (59.72 +/- 18.69 minutes and 66.17 +/- 18.44 minutes, respectively, P = 1.000). The average time to achieve N2 sleep was 32.38 minutes in the chloral hydrate group and 43.25 minutes in the melatonin group (P < 0.001). Both time spent in wakefulness and N1 sleep were found to be significantly higher in the melatonin group (P < 0.001 and P = 0.005). BIS scores higher than 75 were found to be suggestive for wakefulness; 75 to 66 for N1, 65 to 46 for N2, and values lower than 46 were found to be indicative for N3 sleep with a good strength of agreement in weighted Kappa analysis (95% confidence interval; weighted Kappa = 0.67). Conclusions: Melatonin is reliable and at least as effective as chloral hydrate for sleep EEG acquisition in children.en10.1097/WNP.0000000000000829info:eu-repo/semantics/closedAccessBispectral indexChildrenChloral hydrateMelatoninSleep EEGSedationDeprivationHydroxyzineEegDepthArticle397625630WOS:0008787465000162-s2.0-8514188984833606431Q2Q3