Akdemir O.Lineaweaver W.C.Cavusoglu T.Binboga E.Uyanikgil Y.Zhang F.Pekedis M.Yagci T.2019-10-262019-10-2620150300-8207https://doi.org/10.3109/03008207.2015.1026437https://hdl.handle.net/11454/17376Taurine has anti-inflammatory and antioxidant characteristics. We have introduced taurine into a tendon-healing model to evaluate its effects on tendon healing and adhesion formation. Two groups of 16 rats underwent diversion and repair of the Achilles tendon. One group received a taurine injection (200mg/ml) at the repair site, while the other group received 1ml of saline. Specimens were harvested at 6 weeks and underwent biomechanical and histological evaluation. No tendon ruptured. Average maximum load was significantly greater in the taurine-applied group compared with the control group (p<0.05). Similarly, average energy uptake was significantly higher in the taurine-applied group compared with the control group (p<0.05). We observed no significant differences in stiffness in both groups (p>0.05). After histological assessment, we found that fibroblast proliferation, edema, and inflammation statistically decreased in the treatment group (p<0.05). These findings could indicate greater tendon strength with less adhesion formation, and taurine may have an effect on adhesion formation. © 2015 Informa Healthcare USA, Inc.en10.3109/03008207.2015.1026437info:eu-repo/semantics/closedAccessAntiadhesionfibrosisratstaurinetendon healingArticle56430030625749029Q2