Lambrecht, Fatma YurtOcakoglu, KasimColak, Suleyman GokhanErsoz, Onur AlpEr, Ozge2019-10-272019-10-2720171747-02771747-0285https://doi.org/10.1111/cbdd.12935https://hdl.handle.net/11454/31971Imidazolium salts and derivatives have antitumor efficacy and toxic effects in different micro-organisms. In this study, an imidazolium bromide salt (NMI) was synthesized, and its antitumor potential was investigated by in vitro studies. Radiolabeling of synthesized NMI was carried out by iodogen method using I-131 radionuclide. The yield of radiolabeling was determined as 98.5 +/- 0.1%. After that, cytotoxicity and intracellular uptake studies were evaluated in various cell lines. The cytotoxicity of NMI was determined as 35, 20, 10, and 1 mu m for HEK-293, PC-3, CaCo-2, and MCF-7 cells, respectively. In addition, the intracellular uptake of I-131-NMI was investigated in the cell lines, and the uptake was significantly found as 4 hr for MCF-7 and 6 hr for PC-3. In future studies, antitumor efficacy of I-131-NMI on tumor-bearing animal model might be studied in light of these results.en10.1111/cbdd.12935info:eu-repo/semantics/closedAccessI-131anticancer potentialimidazolium saltsnuclear medicineRadiolabelingArticle901141146WOS:00040510260001228067001Q2Q3