Moharrami P.Unak P.Guldu O.K.Medine E.I.Gumuser G.Bilgin E.S.Aras O.2019-10-272019-10-2720170236-57310236-5731https://doi.org/10.1007/s10967-017-5630-2https://hdl.handle.net/11454/25338A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies. © 2017, Akadémiai Kiadó, Budapest, Hungary.en10.1007/s10967-017-5630-2info:eu-repo/semantics/closedAccessBreast cancerCancer imagingDiethylstilbestrolLung cancerProstate cancerQuantum dot nanoparticlesArticle314326092620Q2