Buduneli N.2021-05-032021-05-0320182196-30022196-3002https://doi.org/10.1007/s40496-018-0166-2https://hdl.handle.net/11454/70721Purpose of Review: This review examines the current literature on periodontal treatment, bacteremia and prophylactic antibiotic usage to prevent the systemic adverse outcomes. Recent Findings: Currently, it is not clear whether prophylactic antibiotic administration prevents bacterial endocarditis in patients with high risk. Summary: Recent publications have resulted in significant changes in the concept of antibiotic prophylaxis. Available evidence does not support the previously published guidelines recommending prophylactic antibiotic usage prior to dental treatment. Potential harms and costs of antibiotic administration should be weighed against expected benefits. Clinicians are advised to discuss the potential benefits and harms of antibiotic prophylaxis with their patients before prescription. © 2018, Springer International Publishing AG, part of Springer Nature.en10.1007/s40496-018-0166-2info:eu-repo/semantics/closedAccessAntibioticsBacteremiaBacterial endocarditisPeriodontal diseasesPeriodontal treatmentReview Article5119252-s2.0-85100678906Q2