Ozyar B.Uyar M.Uyar M.Koca U.Mert S.Ugur G.2019-10-272019-10-2719961016-51501016-5150https://hdl.handle.net/11454/23885The effect of 0.15 mg oral clonidine premedication and intrathecally administered clonidine on sensory blockade of bupivacaine spinal anaesthesia in 45 ASA I-II patients scheduled for urological surgery are compared. Patients received 0.15 mg clonidine PO in the first group, 5 mg diazepam in the second and third groups 60-90 min. before the operation. Spinal anaesthesia was performed with 3 mL plain bupivacaine plus 1 ml 0.9 % NaCl in the first and the third groups, and with 3 mL plain bupivacaine plus 1 mL (=0.15 mg) clonidine in the second group. No significant difference was observed in maximal sensory level and onset time among three groups. The mean time to two-segment regression and regression to L2 segment was significantly longer in intrathecal clonidine group compared to other groups (p<0.05). Adding of clonidine to plain bupivacaine significantly prolonged the duration of spinal anaesthesia while oral clonidine premedication caused no significant change.trinfo:eu-repo/semantics/closedAccessClonidineSpinal anaesthesiaArticle244176179N/A