Aydinok, Yesim2019-10-272019-10-2720180889-85881558-1977https://doi.org/10.1016/j.hoc.2017.12.002https://hdl.handle.net/11454/30551Introduction of MRI techniques for identifying and monitoring tissue iron overload and the current understanding of iron homeostasis in transfusion-dependent (TDT) and non transfusion-dependent thalassemia have allowed for a more robust administration of iron chelation therapies. The development of safe and efficient oral iron chelators and the insights gained from large-scale prospective studies using these agents have improved iron overload management. A significant reduction in iron toxicity induced morbidity and mortality and improvements in quality of life were observed in TDT. The appropriate management of tissue-specific iron loading in TDT has been portrayed using evidence-based data obtained from investigational studies.en10.1016/j.hoc.2017.12.002info:eu-repo/semantics/closedAccessThalassemia majorThalassemia intermediaTransfusion-dependent thalassemiaNon-transfusion dependent thalassemiaChelationLiver iron concentrationCardiac ironSerum ferritinArticle322261+WOS:00042846210001029458731Q2Q2