Alan, MuratSorsa, TimoMeric Kantar, PinarRaisanen, Ismo T.Gurlek, OnderKanmaz, BurcuBuduneli, Nurcan2025-03-202025-03-202024Alan, M., Sorsa, T., Kantar, P. M., Raisanen, I. T., Gurlek, O., Kanmaz, B., & Buduneli, N. (2024). Active-matrix metalloproteinase-8, myeloperoxidase in relation with periodontics, preterm birth. Oral Diseases.1354523Xhttps://doi.org/10.1111/odi.15202https://hdl.handle.net/11454/116856Objective: To investigate serum, placental levels of active-matrix metalloproteinase-8 (aMMP-8), myeloperoxidase (MPO) in preterm-birth with/without pre-eclampsia and term counterparts in relation with clinical periodontal parameters. Methods: Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full-term (FT), pre-term (PT) or pre-term complicated by pre-eclampsia (PTPE) deliveries. aMMP-8 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non-parametric tests. Results: PTBE group exhibited higher full-mouth probing depth and clinical attachment loss values than the other two groups (p < 0.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in the other groups (p < 0.05). Serum aMMP-8 and MPO concentrations were higher in PTPE group than in the other groups (p < 0.05). Placenta aMMP-8 level was higher in the control group than in the PTPE group (p < 0.05). There was no significant difference between the groups in the placenta MPO levels (p > 0.05). Conclusions: Within the limits of this cross-sectional study, it may be suggested that serum aMMP-8 and MPO concentrations together with placenta aMMP-8 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.en10.1111/odi.15202info:eu-repo/semantics/closedAccessMMP-8MPOperiodontal diseaseplacentapreeclampsiapreterm birthArticleNov19WOS:0013583126000012-s2.0-8520909138239543825Q1Q1