Deniz, M. N.Sertoz, N.Erhan, E.Ugur, G.2019-10-272019-10-2720120300-06051473-2300https://doi.org/10.1177/030006051204000635https://hdl.handle.net/11454/46395OBJECTIVE: The impact of preoperative gabapentin on tramadol consumption using patient-controlled analgesia (PCA) and postoperative pain was assessed in patients undergoing radical retropubic prostatectomy (RRP). METHODS: In this prospective, randomized trial, 51 patients undergoing RRP were randomized into two groups: the gabapentin group received 900 mg gabapentin orally 2 h before surgery; the control group did not receive gabapentin. Postoperative analgesia was provided by tramadol PCA. Pain was assessed using a visual analogue scale for, 24 h, postoperatively. RESULTS: Mean cumulative tramadol consumption at 24 h was comparable in the two groups. Pain scores at 45 min, 60 min and 2 h postoperatively, and the number of patients who required rescue analgesia, were significantly lower in the gabapentin group than in the control group. Side-effects were similar in the two groups. CONCLUSIONS: Preoperative administration of 900 mg gabapentin did not decrease tramadol consumption, but was associated with lower pain scores in the early postoperative phase and a reduced need for rescue analgesia, compared with controls, in patients undergoing RRP.en10.1177/030006051204000635info:eu-repo/semantics/openAccessGABAPENTINPOSTOPERATIVE PAINRADICAL RETROPUBIC PROSTATECETOMYRESCUE ANALGESIATRAMADOL CONSUMPTIONArticle40623622369WOS:00031353830003523321194Q3Q4