Ertay T.Unak P.Tasci C.Biber F.Z.Zihnioglu F.Durak H.2019-10-272019-10-2720050236-57310236-5731https://doi.org/10.1007/s10967-005-0851-1https://hdl.handle.net/11454/27750The aim of this study was to label exorphin C with 99mTc and to examine its usefulness as opioid receptor binding radiopharmaceutical in Albino Wistar rats. Exorphin C, which is a peptide with 5 aminoacids, was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Labeling efficiency was higher than 98%. The compound was stable for at least 5 hours at room temperature. Mammary tumor bearing Albino Wistar rats were imaged using gamma-camera. Biodistribution studies were also performed. Results demonstrated that 99mTc-glucoheptonate-exorphin C ( 99mTc-GE) analogs may be useful as a new class of receptor-binding peptides for the diagnosis and therapy of some cancer diseases related with opioid receptor-expressing tissues. © 2005 Akadémiai Kiadó.en10.1007/s10967-005-0851-1info:eu-repo/semantics/closedAccessArticle2653473479Q2