Karabay-Yavasoglu N.U.Karamenderes C.Baykan S.Apaydin S.2019-10-272019-10-2720071388-02091388-0209https://doi.org/10.1080/13880200601113149https://hdl.handle.net/11454/27583The ethanol extract of Achillea nobilis L. subsp. neilreichii (Kerner) Formanék (Asteraceae) flower heads was investigated for its antinociceptive and anti-inflammatory activities and for acute toxicity in mice and rats. While the extract exhibited an antinociceptive effect during the late phase of the formalin test (100, 200, and 400 mg/kg, i.p.) and an anti-inflammatory effect in the paw edema test (100 and 200 mg/kg, i.p.), it did not exert any significant antinociceptive effect in the tail-flick test. Furthermore, administration of 400 mg/kg extract increased the latency to hot-plate test at 60 and 90 min. No significant change was detected in sensory motor performance. The acute LC50 value of the extract was 4456 mg/kg (i.p.) in mice. The current results demonstrate that an ethanol extract of A. nobilis L. subsp. neilreichii exerts anti-inflammatory activity. © 2007 Informa Healthcare.en10.1080/13880200601113149info:eu-repo/semantics/openAccessAchillea nobilisAcute toxicityAnti-inflammatoryAntinociceptiveAsteraceaeSubsp. neilreichiiArticle452162168Q1