Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid ?1-42 Aggregation

Irisli, SevilGuennaz, SalihOezcan, OezgeAri, AydanMaral, MeltemErdem, ArzumOezel, Derya2024-08-312024-08-3120240268-26051099-0739https://doi.org/10.1002/aoc.7540https://hdl.handle.net/11454/104284For synthesizing metal-organic molecules with pro-drug properties to prevent the accumulation of amyloid beta (A beta(1-42)), which is a feature of neurodegenerative Alzheimer's disease, two new Schiff bases with imine/amine donors 2-([3,3-diphenylalidene]amino)-N,N-dimethylethane-1-amine and N,N-dimethyl-2-([quinolin-4-ylmethylene]amino)ethane-1-amine, as well as their novel Pt (II) complexes (I and II), were synthesized and characterized via Fourier transform infrared spectroscopy, H-1- and C-13-nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and elemental analyses. The spectroscopic data has shown that the ligands are coordinated to the central atom in a chelating manner. Furthermore, the interaction between these complexes and A beta(1-42) was investigated using the electrochemical methods, square wave voltammetry and pencil graphite electrode, while monitoring the changes in the oxidation signal of the Try residue in A beta(1-42). The ability of the compounds to inhibit A beta(1-42) aggregation was investigated using the human neuroblastoma cell line (SH-SY5Y). Complex II could actively inhibit the aggregation of A beta(1-42) at a molar ratio of 1.0/1.0, and its A beta(1-42) aggregation kinetics were fluorometrically determined using thioflavin T. These results were supported by scanning electron microscopy and transmission electron microscopy analyses. Moreover, the interaction of complex II with A beta(1-16) was investigated via H-1-NMR spectroscopy. As a result, it was observed that complex II was effective in inhibiting the aggregation of A beta(1-42) at a molar ratio of 1.0/1.0. This result shows that studies can be conducted on the effects of Schiff base-Pt complexes as potential pro-drugs on Alzheimer's disease.en10.1002/aoc.7540info:eu-repo/semantics/openAccessAnti-Alzheimer ActivityPlatinum ComplexesSchiff BasePlatinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid ?1-42 AggregationArticle388WOS:0012377433000012-s2.0-85195126833Q2N/A