Macrophage migration inhibitory factor expression and MIF gene - 173 G/C polymorphism in nonalcoholic fatty liver disease
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To investigate the macrophage migration inhibitory factor (MIF) expression and - 173 G/C polymorphism of the MIF gene in nonalcoholic fatty liver disease (NAFLD). Method: Ninety-one patients with diagnosis of NAFLD and 104 healthy controls were included in the study. MIF - 173 G/C polymorphism was detected using the PCR-restriction fragment length polymorphism based method. NAFLD was stratified as nonalcoholic steatohepatitis (NASH), probable NASH and steatosis, respectively in groups 1, 2 and 3, according to NAFLD Activity Score. MIF expression was detected by immunohistochemistry staining. Results: Mean age of the patients was 50.1±9.6 years, and 54 of them were male. Serum alanine aminotransferase and aspartate aminotransferase were 50/83, 42/63 and 31/32, respectively in groups 1, 2 and 3, (P<0.05). Both the MIF expression of hepatocytes and mononuclear cells were more prominent in groups 1 and 2 than group 3. There was no correlation between MIF expression of hepatocytes and fibrosis stage. However, MIF expression of mononuclear cells significantly increased according to fibrosis stage (P<0.05, R:0.2). There was no significant correlation between MIF genotype and MIF expression in the liver. Conclusion: MIF expression is significantly increased especially by mononuclear cells in liver tissue of patients with NASH secondary to inflammation. Thus, it should be considered as a consequence not a causal factor. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Açıklama
Anahtar Kelimeler
Gene polymorphism, Liver, Macrophage migration inhibitory factor, Nonalcoholic fatty liver disease
Kaynak
European Journal of Gastroenterology and Hepatology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
22
Sayı
2
