HIV pozitif kişilerde cinsel yolla bulaşan etkenlerin sıklığı
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Dosyalar
Tarih
2018
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Yayıncı
Ege Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AMAÇ: Bu çalışmada, HIV pozitif kişilerdeki cinsel yolla bulaşan hastalık etkenlerinden Neisseria gonorrhoeae , Chlamydia trachomatis, Trichomonas vaginalis Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum, Herpes simpleks virüs tip 1 ve 2, Human Papilloma virüs'ün 19 yüksek riskli genotipi ve 9 düşük riskli genotipini taramak ve etkenlerin sıklığını araştırmak amaçlanmıştır. GEREÇ ve YÖNTEM: Eylül 2015 ile Nisan 2016 tarihleri arasında, 90 [14’ü kadın (%15.6), 76’sı erkek (%84.4)] HIV pozitif hastadan vajinal ve üretral sürüntü örnekleri toplandı. Bakteriyel ve parazit etkenleri çoklu olarak amplifiye edildi (AnyplexTM II STI-7 Detection (V1.1), Seegene, Güney Kore). HPV için üretici firma (Anyplex II HPV28 Detection kit, Seegene, Güney Kore) protokolü uygulandı. HSV tip 1-2 saptanmasında HSV 1/2 Qual Kit (Roche Diagnostics GmbH, Mannheim, Almanya ) kullanıldı. BULGULAR: HIV pozitif hastaların 49’unda (%54,4) en az bir cinsel yolla bulaşan etken pozitif bulundu. Trichomonas vaginalis, HSV-1 ve HSV-2, klinik örneklerin hiç birinde saptanmadı. Örneklerin 31'inde (%34,4) HPV, 20'sinde (%22,2) U. urealyticum, 15'inde (%16,6) U. parvum, 8'indee(%8,8) M. genitalium, 8'inde (%8,8) M. hominis, 5'inde (%5,5) N. gonorrhoeae, 2'sinde (%2,2) C. trachomatis, saptandı. SONUÇ: HIV (+) kişilerin yaklaşık %55’inde etken pozitif bulunmuştur. Bu hastaların %35’inde çoklu etken saptanmıştır. HIV(+) kişilerde en sık rastlanan ilk üç etken sırasıyla HPV (%35), U.urealyticum (%22) ve U.parvum (%17) olmuştur. HPV enfeksiyonunun hastanemize başvuran HIV pozitif hastalarda önemli bir cinsel yolla bulaşan etken olduğu görülmüştür ve herhangi bir belirti göstermeyen hastalarda bile etkene yönelik tarama yapılması sonucuna varılmıştır.
OBJECTIVE: The aim of this study was to investigate the effects of sexually transmitted disease agents such as N. gonorrhoeae, C. trachomatis, T. vaginalis, M. genitalium, M. hominis, U. urealyticum, U. parvum, HSV 1 and HSV 2, 19 high risk genotype HPV and 9 low risk genotype and determining the frequency of the agents in HIV-positive individuals. MATERIALS AND METHODS: Between September 2015 and April 2016, vaginal and urethral swab samples were collected from 90 HIV positive patients (14 female, 15.6% male, 84.4%). The factors of STI were amplified with AnyplexTM II STI-7 Detection (V1.1) (Seegene, South Korea). Amplification of nucleic acid was performed Anyplex II HPV28 Detection kit (Seegene, South Korea). HSV type 1-2 were performed Light-Cycler HSV 1/2 Qual Kit (Roche Diagnostics GmbH, Mannheim, Germany). RESULTS: At least one sexually transmitted agent was positive in 49 (54.4%) of the HIV-positive patients. Trichomonas vaginalis, HSV-1 and HSV-2 were not detected in any of the clinical specimens. HPV was found in 31 (%34,4), U. urealyticum in 20 (22.2%), U. parvum in 15 (16.6%), M. genitalium in 8 (8.8%), , M. hominis in 8 (8.8%), N. gonorrhoeae in 5 (5.5%) and C. trachomatis in 2 (2.2%). CONCLUSION: Approximately 55% of HIV (+) individuals without any sexually transmitted disease were found to have one or more non-HIV sexually transmitted agents positive. More than one human papillomavirus serotypes were detected in 35% of these patients. HPV positive patients were referred to the clinic for follow up.
OBJECTIVE: The aim of this study was to investigate the effects of sexually transmitted disease agents such as N. gonorrhoeae, C. trachomatis, T. vaginalis, M. genitalium, M. hominis, U. urealyticum, U. parvum, HSV 1 and HSV 2, 19 high risk genotype HPV and 9 low risk genotype and determining the frequency of the agents in HIV-positive individuals. MATERIALS AND METHODS: Between September 2015 and April 2016, vaginal and urethral swab samples were collected from 90 HIV positive patients (14 female, 15.6% male, 84.4%). The factors of STI were amplified with AnyplexTM II STI-7 Detection (V1.1) (Seegene, South Korea). Amplification of nucleic acid was performed Anyplex II HPV28 Detection kit (Seegene, South Korea). HSV type 1-2 were performed Light-Cycler HSV 1/2 Qual Kit (Roche Diagnostics GmbH, Mannheim, Germany). RESULTS: At least one sexually transmitted agent was positive in 49 (54.4%) of the HIV-positive patients. Trichomonas vaginalis, HSV-1 and HSV-2 were not detected in any of the clinical specimens. HPV was found in 31 (%34,4), U. urealyticum in 20 (22.2%), U. parvum in 15 (16.6%), M. genitalium in 8 (8.8%), , M. hominis in 8 (8.8%), N. gonorrhoeae in 5 (5.5%) and C. trachomatis in 2 (2.2%). CONCLUSION: Approximately 55% of HIV (+) individuals without any sexually transmitted disease were found to have one or more non-HIV sexually transmitted agents positive. More than one human papillomavirus serotypes were detected in 35% of these patients. HPV positive patients were referred to the clinic for follow up.
Açıklama
Anahtar Kelimeler
Cinsel Yolla Bulaşan Hastalıklar, HIV, Klamidya, Gonore, Sexually Transmitted Diseases, HIV, Chlamydia, Gonorrhea
