Amino acid neurotransmitter levels in the cerebral cortex of mice receiving imipenem / cilastatin-lack of excitotoxicity in the central nervous system
Küçük Resim Yok
Tarih
1998
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Imipenem, a very potent car-bapenem derivative beta-lactam antibiotic, has recently found a major place in the treat-ment of antibiotic-resistant nosocomial infec-tions. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhi-bition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divid-ed into three equal groups and given thera-peutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of Imipenem/cilastatine (UC) or saline solution intraperitoneally for 7 days. All animals in the excessive dose group showed seizure-like acivity with ataxia and loss of gait. However, no differences in aspar-tate, glumatate, glycine or GABA levels were seen on gas Chromatographie evaluation of the cerebral cortexes of all three groups of animals, which were dispatched on the 7th day. Therefore it is suggested that imipenem exerts its convulsive effect without causing any change in neurotansmitter levels of barin, possibly by effecting the neuronal receptors directly.
Imipenem, a very potent car-bapenem derivative beta-lactam antibiotic, has recently found a major place in the treat-ment of antibiotic-resistant nosocomial infec-tions. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhi-bition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divid-ed into three equal groups and given thera-peutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of Imipenem/cilastatine (UC) or saline solution intraperitoneally for 7 days. All animals in the excessive dose group showed seizure-like acivity with ataxia and loss of gait. However, no differences in aspar-tate, glumatate, glycine or GABA levels were seen on gas Chromatographie evaluation of the cerebral cortexes of all three groups of animals, which were dispatched on the 7th day. Therefore it is suggested that imipenem exerts its convulsive effect without causing any change in neurotansmitter levels of barin, possibly by effecting the neuronal receptors directly.
Imipenem, a very potent car-bapenem derivative beta-lactam antibiotic, has recently found a major place in the treat-ment of antibiotic-resistant nosocomial infec-tions. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhi-bition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divid-ed into three equal groups and given thera-peutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of Imipenem/cilastatine (UC) or saline solution intraperitoneally for 7 days. All animals in the excessive dose group showed seizure-like acivity with ataxia and loss of gait. However, no differences in aspar-tate, glumatate, glycine or GABA levels were seen on gas Chromatographie evaluation of the cerebral cortexes of all three groups of animals, which were dispatched on the 7th day. Therefore it is suggested that imipenem exerts its convulsive effect without causing any change in neurotansmitter levels of barin, possibly by effecting the neuronal receptors directly.
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Kaynak
Turkish Journal of Medical Sciences
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Scopus Q Değeri
Cilt
28
Sayı
5
