İzmir'de von Willebrand hastalığı sıklığını belirlemeye yönelik epidemiyolojik çalışma
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Von Willebrand Hastalığı (vWH) von Willebrand faktörün nitelik veya niceliksel bozukluğundan kaynaklanan otozomal geçişli kalıtsal bir hastalıktır. En sık görülen kalıtsal kanama bozukluğu olarak kabul edilir. Bu çalışmada amaç İzmir'de vVVH'nın görülme sıklığını belirlemektir. Yaşları 6- 13 yıl arasında değişen toplam 3485 çocuğa kendilerinde ve ailelerinde kanama semptomlarının varlığını, varsa ağırlığını belirlemeye yönelik bir anket formu verildi. Anne ve babaları tarafından bu anket formları dolduruldu ve 3179 çocuğun anket formu geri alındı. Kanama bulguları olan ve ailesinde kendisinden başka en az 1 bireyde daha kanama öyküsü tanımlanan çocuklardan vWf antijen (vWf: Ag) ve aktivitesi (RiCof) çalışılmak üzere kan örneği alınması önerildi. Kişisel kanama semptomları bulunan ve ailesinde kanama öyküsü tanımlanan 194 çocuğun 179'undan kan örneği alındı. Tetkikler sonucunda 14 çocukta azalmış vWf:Ag ve/ veya RiCof değerleri saptandı. İzmir ilinde okul çocuklarında vWH görülme sıklığı % 0.44 olarak belirlendi.
Von Willebrand Disease is an autosomally inherited disease resulting from a quantitative or qualitative defect of von Willebrand factor (vWf). It is considered as the most common cause of hereditary bleeding disorders. The aim of this study was to evaluate the prevalence of vWD in Izmir. A total of 3485 children aged 6-13 years attending at six different primary and secondary school in Izmir were given a questionnaire form to determine the presence of bleeding symptoms and their severity in children and their families. Questionnaire forms were completed by parents and turned back from 3179 children. Children who had bleeding symptoms and at least one other family member with a bleeding history were asked to give blood samples for vWf antigen (vWf: Ag) and its activity (RiCof). A total of 179 children out of 194 who had personal and family history of bleeding accepted to participate in the study and gave the blood samples. Blood analysis revealed decreased vWf: Ag and/or RiCof in 14 children. The prevalence of vWD among the school children in Izmir was found to be.0.44%. In this study the most common bleeding symptoms in children with vWD were easy bruising and epistaxis.
Von Willebrand Disease is an autosomally inherited disease resulting from a quantitative or qualitative defect of von Willebrand factor (vWf). It is considered as the most common cause of hereditary bleeding disorders. The aim of this study was to evaluate the prevalence of vWD in Izmir. A total of 3485 children aged 6-13 years attending at six different primary and secondary school in Izmir were given a questionnaire form to determine the presence of bleeding symptoms and their severity in children and their families. Questionnaire forms were completed by parents and turned back from 3179 children. Children who had bleeding symptoms and at least one other family member with a bleeding history were asked to give blood samples for vWf antigen (vWf: Ag) and its activity (RiCof). A total of 179 children out of 194 who had personal and family history of bleeding accepted to participate in the study and gave the blood samples. Blood analysis revealed decreased vWf: Ag and/or RiCof in 14 children. The prevalence of vWD among the school children in Izmir was found to be.0.44%. In this study the most common bleeding symptoms in children with vWD were easy bruising and epistaxis.
Açıklama
Anahtar Kelimeler
Pediatri
Kaynak
Ege Pediatri Bülteni
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
3
