Voltammetry of the anticancer drug mitoxantrone and DNA
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Scientific Technical Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The interaction of mitoxantrone (MTX) with calf thymus double-stranded DNA (dsDNA) and calf thymus single-stranded DNA (ssDNA) was studied electrochemically by using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) at a carbon paste electrode (CPE). The changes in the experimental parameters (the concentration of MTX, the concentration of DNA and the accumulation time of MTX) were studied by DPV; in addition, the detection limit and the reproducibility were determined. It was observed for the interaction of MTX with dsDNA and ssDNA that the signal of the bare electrode was higher than the signal of the dsDNA modified CPE. The signals in the cyclic voltammograms were found to be decreasing in the following order: bare CPE, ssDNA modified and dsDNA modified CPE.
Açıklama
Anahtar Kelimeler
mitoxantrone, biosensors, DNA, voltammetry, intercalation
Kaynak
Turkish Journal of Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
25
Sayı
4
