DNA topoisomerases as targets for anticancer drugs
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth. Over the past few years there has been considerable pharmacological interest in these enzymes because inhibitors of DNA topoisomerases represent a major class of anticancer drugs. This review highlights topoisomerase-targeting drugs that have shown promising anticancer activities. The mechanisms by which those drugs interfere with the catalytic cycles of type I and type II DNA topoisomerases and the factors involved in the development of resistance to these drugs are discussed.
Açıklama
Anahtar Kelimeler
anticarcinogenic drug, multi-drug resistance, type I DNA topoisomerase, type II DNA topoisomerase
Kaynak
Journal of Clinical Pharmacy and Therapeutics
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
26
Sayı
6
