Yaşa bağlı maküla dejenerasyonu hastalarında fotodinamik tedavi sonuçları
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada fotodinamik tedavinin yaşa bağlı maküla dejenerasyonda gelişen koroidal neovaskülarizasyonların tedavisindeki etkinliği değerlendirildi. Gereç ve Yöntem: Çalışmaya 30 hastanın 30 gözü alındı. Hastaların 16’sı (%53.3) erkek, 14’ü (%47.7) kadındı. Hastaların yaş ortalaması 68.4±8.74 (47-81 yaş), ortalama takip süresi 15.7±3.28 ay (10-22 ay) idi. Tedavi öncesi hastaların en iyi düzeltilmiş görme keskinlikleri Early Treatment of Diabetic Retinopathy Study 2 numaralı eşeli ve lezyon tipleri ve lezyon büyüklükleri fundus kamera ile ölçüldü. Hastalara fotodinamik tedavi endikasyonu Avrupa Oftalmoloji Cemiyeti’nin 2001 yılında yayınladığı rehbere göre kondu. Hastalar FDT sonrası 1. hafta, 3. ay ve sonrasında her üç ayda bir kontrol edildi. Kontrollerde ETDRS eşeli ile en iyi düzeltilmiş görme keskinlikleri, fundus muayeneleri ve fundus kamera ile renkli fundus görüntüleri alındı ve özellikle ilk ve ikinci kontrollerde FFA’ları çekildi. Hastalar kontrollerinde FFA’daki florosein sızdırma özelliklerine göre dört gruba ayrıldılar ve sızıntının olmadığı durumlar ile sızıntının %50’den daha az hale geldiği durumlarda tedavi başarılı, sızıntının %50’den fazla olduğu durumlarda ise başarısız kabul edildi. Bulgular: Ortalama 2±1.44 (1-5) seanslık tedavi sonucunda 22 (%73.3) olguda KNV’nin gerilediği, 8 (%27.7) olguda ise KNV’nin devam ettiği tespit edildi. Başarılı grupla başarısız grup görme kaybı açısından değerlendirildiğinde başarılı grupta ortalama 1.5 LogMAR standart sırası daha az görme kaybı gelişti fakat aradaki fark istatistiksel olarak anlamlı değildi. (p=0.101). Tartışma: Sonuç olarak Verteporfin ile FDT ile Eksudatif tip YBMD tedavisinde etkili ve güvenli bir yöntemdir.
Purpose: To evaluate the efficacy of photodynamic therapy in patients who had choroidal neovascularization due to agerelated macular degeneration (AMD). Materials and Methods: Data on 30 eyes of 30 patients were evaluated. Sixteen patients were men and 14 were women. Mean age was 68.4±8.74 (47 to 81 years) years. Mean follow-up time was 15.7±3.28 months (10-22 months). The patients’ best corrected visual acuities were measured by Early Treatment of Diabetic Retinopathy Study (ETDRS) chart number 2 and lesion types and the GLD of the lesions were measured by Topcon Image Net Fundus Camera. The indication for photodynamic therapy was based on the European Ophthalmology Society’s criteria published in 2001. The patients were invited to undergo control examinations 1 week and 3 months after the therapy and thereafter every 3 months. In each control examination the best corrected visual acuity was checked by ETDRS chart, fundus examinations were performed and fundus photographs were recorded by fundus camera, and FFA examinations was performed, especially in the first and second controls. Results: After 2±1.44 therapies (ranging from 1 to 5) 22 patients (73.3%) could have been treated, but 8 patients (27.7%) had persistent CNVs. There was no significant difference in visual loss between the two groups but the loss in the successful group was 1.5 LogMAR standard lines less than that in the unsuccessful group.
Purpose: To evaluate the efficacy of photodynamic therapy in patients who had choroidal neovascularization due to agerelated macular degeneration (AMD). Materials and Methods: Data on 30 eyes of 30 patients were evaluated. Sixteen patients were men and 14 were women. Mean age was 68.4±8.74 (47 to 81 years) years. Mean follow-up time was 15.7±3.28 months (10-22 months). The patients’ best corrected visual acuities were measured by Early Treatment of Diabetic Retinopathy Study (ETDRS) chart number 2 and lesion types and the GLD of the lesions were measured by Topcon Image Net Fundus Camera. The indication for photodynamic therapy was based on the European Ophthalmology Society’s criteria published in 2001. The patients were invited to undergo control examinations 1 week and 3 months after the therapy and thereafter every 3 months. In each control examination the best corrected visual acuity was checked by ETDRS chart, fundus examinations were performed and fundus photographs were recorded by fundus camera, and FFA examinations was performed, especially in the first and second controls. Results: After 2±1.44 therapies (ranging from 1 to 5) 22 patients (73.3%) could have been treated, but 8 patients (27.7%) had persistent CNVs. There was no significant difference in visual loss between the two groups but the loss in the successful group was 1.5 LogMAR standard lines less than that in the unsuccessful group.
Açıklama
Anahtar Kelimeler
Göz Hastalıkları
Kaynak
Retina-Vitreus
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
4
