Synthesis, crystal structures and antimicrobial activities of 3-methyl and 3-bromo substituted benzo[b]thiophene based thiosemicarbazones
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A series of thiosemicarbazones (TSCs) (L1-5) containing benzothiophen moiety were prepared via the reaction of 3-methyl/3-bromobenzo[b]thiophene-2-carboxaldehyde with appropriate thiosemicarbazides. The compounds were confirmed by elemental analysis, FT-IR, H-1 NMR, MALDI-TOF and single crystal X-Ray diffraction techniques. The compounds exist in the E conformation with respect to the azomethine C = N double bond as confirmed by their C8/C9/N1/N2 torsion angles being 178.4(2)degrees (L-1), - 175.2(5)/177.4(5)degrees (L-2), 177.5(2)degrees (L-3), 179.7(3)degrees (L-4), and - 177.4(7)degrees (L-5). These compounds were researched for their antibacterial activity against Grampositive bacteria (E. faecalis and S. aureus), Gram-negative bacteria (E. coli, P. aeruginosa and S. marcescens) and antifungal activity against a yeast species C. albicans. The ligands possessed varying degrees of antimicrobial activity. Generally, the compounds demonstrated higher efficacy against gram-positive bacteria than gram-negative ones. The antifungal activity of the compounds against C. albicans was found to be lower in comparison to their activity against bacteria.
Açıklama
Anahtar Kelimeler
Benzothiophene, thiosemicarbazone, crystal structure, antimicrobial activity, antifungal activity, Metal-Complexes, Nickel(Ii), Semicarbazone, Palladium(Ii), Cobalt(Ii), Thiophene, Patterns, Zinc(Ii)
Kaynak
Journal of Sulfur Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
