Meme kanserimde yerel kontrole etki eden prediktif moleküler ve genetik faktörler
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Meme kanseri farklı histolojik alt tiplerden oluşan heterojen bir grup olup bu değişkenliklerin altında molekuler ve genetik faktörler yatmaktadır. Meme koruyucu cerrahi sonrası her hastaya radyoterapi verilirken aslında hastaların üçte ikisi boşuna radyoterapi almaktadır. Bu nedenle hangi hastaların tedavi alması gerektiği çok önem kazanmaktadır. Bilinen klinik ve histopatolojik prognostik faktörler bu konuda yerel kontrolü tahmin etmede yardımcı olmaya yetmemektedir. Günümüzde genetik ve biyoteknolojik gelişmeler moleküler onkolojide büyük aşamalara neden olmuş, bu durum klinik onkolojiye yansımıştır. Bu yazıda meme kanserinde yerel kontrole etkili olabilecek molekuler ve genetik prediktif faktörler üzerinde durulmuş, moleküler sınıflama, multigen testler, radyoterapi direnci, DNA tamir kapasitesi, sinyal yolakları, kanser kök hücreleri, CYP2D6 inhibisyonu gibi etkenlerin yerel kontrol üzerindeki prediktif değeri için yapılan çalışma sonuçlarından bir derleme hazırlanmıştır.
Breast cancer is a heterogeneous group of different histological subtypes, which are based on various molecular and genetic factors. All patients are given radiotherapy after breast-conserving surgery, which is actually considered unnecessary in two-thirds of these patients. Therefore, the fact that which patients should be administered radiotherapy has gained great importance. In this respect, known clinical and histopathological prognostic factors can not be sufficient to predict local control. Today, genetic and biotechnological advances caused significant progresses in molecular oncology, which is reflected in clinical oncology. In this article, molecular and genetic predictive factors that could be effective in the local control of breast cancer have been focused on, and a review of studies data conducted on the predictive value of the factors such as molecular classification, multigene tests, radiation resistance, DNA repair capacity, signaling pathways, cancer stem cells, and inhibition of CYP2D6 on local control was presented.
Breast cancer is a heterogeneous group of different histological subtypes, which are based on various molecular and genetic factors. All patients are given radiotherapy after breast-conserving surgery, which is actually considered unnecessary in two-thirds of these patients. Therefore, the fact that which patients should be administered radiotherapy has gained great importance. In this respect, known clinical and histopathological prognostic factors can not be sufficient to predict local control. Today, genetic and biotechnological advances caused significant progresses in molecular oncology, which is reflected in clinical oncology. In this article, molecular and genetic predictive factors that could be effective in the local control of breast cancer have been focused on, and a review of studies data conducted on the predictive value of the factors such as molecular classification, multigene tests, radiation resistance, DNA repair capacity, signaling pathways, cancer stem cells, and inhibition of CYP2D6 on local control was presented.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Meme Sağlığı Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
4
