Lower HbA1c targets are associated with better metabolic control
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Previous studies have suggested that clear HbA1c target setting by the diabetes team is associated with HbA1c outcomes in adolescents. The aim of this study was to evaluate whether this finding is consistent in a larger cohort of children from centers participating in the SWEET international diabetes registry. A questionnaire was sent out to 76 SWEET centers, of which responses from 53 pediatric centers were included (70%). Descriptive outcomes were presented as median with lower and upper quartile. The association between the centers' target HbA1c and mean outcome HbA1c was calculated using linear regression adjusted for age, diabetes duration, sex, and gross domestic product. Median age of the children in the studied centers (n = 35,483) was 13.3 [12.6-14.6] years (49% female). of the 53 centers, 13.2% reported an HbA1c target between 6.0 and 6.5%, 32.1% had a target between >= 6.0 and 7.0%, 18.9% between >= 7.0 and 7.5%, and 3.8% between >= 7.5 and 8.5%. No specific target value was reported by 32.1% of all centers. Median HbA1c across all centers was 7.9 [7.6-8.3] %. Adjusted regression analysis showed a positive association between HbA1c outcome and target HbA1c (p = 0.005). Conclusions: This international study demonstrated that a lower target for HbA1c was associated with better metabolic control. It is unclear whether low target values result in better metabolic control, or lower HbA1c values actually result in more ambitious target values. This target setting could contribute to the differences in HbA1c values between centers and could be an approach for improving metabolic outcomes. What is Known: center dot Target setting of HbA1c is important in children and adolescents with type 1 diabetes. center dot The optimal therapeutic approach of children with type 1 diabetes requires a trained multidisciplinary team. What is New: center dot Lower HbA1c targets are associated with better metabolic control. center dot No associations between the composition of the diabetes teams and metabolic control could be demonstrated
Açıklama
Anahtar Kelimeler
Metabolic control, HbA1c, Children, SWEET
Kaynak
European Journal of Pediatrics
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
180
Sayı
5
