In vitro evaluation, biodistribution in rats of radiolabeled raloxifene
Küçük Resim Yok
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Raloxifene is a selective estrogen receptor modulator that produces both estrogen agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue. In the present study, raloxifene was labeled with I-131 by iodogen method and investigated for its radiopharmaceutical potential. Radiolabeling yield is 91±0.7%, as determined by radio thin layer chromatography (RTLC). Results of in vitro study indicated 131I-raloxifene has high stability (4 h) in serum. Biodistribution study was carried out with Albino wistar female rats. The result has shown that the radioiodinated raloxifene has higher uptake in uterus than breast and ovarian. © 2009 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
131I-raloxifene, I-131, Iodogen, Raloxifene, Rats, Uterus
Kaynak
Applied Radiation and Isotopes
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
68
Sayı
1
