Geriatrik hasta grubunda akut iskemik inme ayırıcı tanısında s-100b protein ölçümünün değeri
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Geriatrik populasyon grubunda sıklıkla izlenen akut iskemik inme tanısı için klinik deneyim ve görüntüleme bulgularını destekleyecek bir kan testine ihtiyaç vardır. Bu çalışmada S100B proteinin akut iskemik inme ve geçici iskemik atak ayırıcı tanısındaki değerinin ortaya konması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Acil Servis'e başvurup, nöroloji konsültasyonu sonucunda klinik bulgular, laboratuvar ve görüntüleme sonuçları birlikte değerlendirilip, akut iskemik inme tanısı alan 55 ve geçici iskemik atak tanılı 20 hasta dahil edilmiştir. Açlık venöz kan örneklerinde ELISA yöntemi ile S100B ölçümü yapılmıştır. Sonuçlar, ortanca (minimum-maksimum) olarak ifade edilmiştir. Bulgular: Akut iskemik inme grubunda [63.86 (50-1876) pg/ml], geçici iskemik atak grubuna [50.14 (<50-87.63) pg/ml] göre anlamlı yüksek S100B değerleri saptanmıştır (p= 0.001). S100B değerlerinin yaş, cinsiyet, beden kitle indeksi, koroner arter hastalığı, diyabetes melitus, hiperlipidemi, kardiyak aritmi, koagulasyon bozukluğu, periferik damar hastalığı, aile hikayesi ve sigara içiminden etkilenmediği görülmüştür. S100B için yapılan ROC (receiver operating curve) analizinde, eğri altında kalan alan 0.836 olarak saptanmıştır (p=0.0001). Sonuç: Hızlı, basit ve düşük maliyetli S100B protein ölçümü, özellikle acil ve yoğun bakım servislerinde, akut iskemik inmenin ayırıcı tanısında erken evrede kullanılabilir.
Introduction: A blood test supporting the clinical and radiological findings used for the diagnosis of acute ischemic stroke (AIS) is needed in the geriatric population. The aim was to demonstrate the value of S100B levels for the differential diagnosis of AIS. Materials and Method: 55 patients who have been diagnosed with AIS after admittance to an emergency room and 20 patients with transient ischemic attack (TIA) were enrolled. AIS diagnosis was based on a neurology consultation in agreement with laboratory and radiological findings. S100B levels were determined in fasting venous blood samples by an ELISA method. The results were expressed as median (minimum-maximum). Results: S100B levels were significantly higher in the AIS group [63.86 (50-1876) pg/ml] than the TIA group [50.14 (< 50- 87.63) pg/ml] (p= 0.001). S100B concentrations were not influenced by age, gender, body mass index or by the presence of coronary artery disease, diabetes mellitus, hyperlipidemia, cardiac arrhythmia, peripheral vascular disease, family history or cigarette smoking. The ROC analysis demonstrated that the area under the curve was 0.836 (p= 0.0001). Conclusion: S100B measurement is a rapid, simple and cost-effective analysis which may be used for the differential diagnosis of AIS in the early stages, especially in emergency and intensive care settings.
Introduction: A blood test supporting the clinical and radiological findings used for the diagnosis of acute ischemic stroke (AIS) is needed in the geriatric population. The aim was to demonstrate the value of S100B levels for the differential diagnosis of AIS. Materials and Method: 55 patients who have been diagnosed with AIS after admittance to an emergency room and 20 patients with transient ischemic attack (TIA) were enrolled. AIS diagnosis was based on a neurology consultation in agreement with laboratory and radiological findings. S100B levels were determined in fasting venous blood samples by an ELISA method. The results were expressed as median (minimum-maximum). Results: S100B levels were significantly higher in the AIS group [63.86 (50-1876) pg/ml] than the TIA group [50.14 (< 50- 87.63) pg/ml] (p= 0.001). S100B concentrations were not influenced by age, gender, body mass index or by the presence of coronary artery disease, diabetes mellitus, hyperlipidemia, cardiac arrhythmia, peripheral vascular disease, family history or cigarette smoking. The ROC analysis demonstrated that the area under the curve was 0.836 (p= 0.0001). Conclusion: S100B measurement is a rapid, simple and cost-effective analysis which may be used for the differential diagnosis of AIS in the early stages, especially in emergency and intensive care settings.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türk Geriatri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
15
Sayı
4
