Phytochemistry and anticholinesterase activities of eight Marrubium taxa
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Marrubium (Lamiaceae) species are traditionally used for their expectorant and antipyretic effects. However, limited research has been conducted on the phytochemical and bioactivity of most species, except M. vulgare L. utilized in both pharmaceutical and food industries. In the present study, the phenolic profiles and marrubiin contents of eight Marrubium taxa, four of which are endemic to T & uuml;rkiye, were investigated. Methanolic extracts were prepared using an ultrasonic bath, while acidic extractions were performed following the instructions outlined in the European Pharmacopoeia. The samples were also evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. The results indicated that all Marrubium taxa contained different amounts of forsythoside B (30-183 mg/100 g dw) and verbascoside (124-287 mg/100 g dw). Elevated levels of tiliroside were detected, particularly within endemic taxa. However, some species did not contain marrubiin, the marker compound of the genus. The highest AChE and BChE inhibitory activities were observed in M. peregrinum. Verbascoside and forsythoside B are candidate molecules as marker compounds for the genus Marrubium. This study provides a detailed chemical composition of one-fifth of the world's Marrubium taxa for the first time. M. anisodon and endemic taxa show potential for the pharmaceutical industry.
Açıklama
Anahtar Kelimeler
anticholinesterase, Endemic, forsythoside B, marrubiin, Marrubium, tiliroside, verbascoside
Kaynak
Plant Biosystems
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
159
Sayı
1
Künye
Demiroz Akbulut, T., Yengin, C., Koyu, H., & Baykan, S. (2024). Phytochemistry and anticholinesterase activities of eight Marrubium taxa. Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 1-13.
