Antioxidant Activities of Phenolic Compounds of Centaurea ensiformis P.H. Davis
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Tarih
2014
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Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmanın amacı endemik Centaurea ensiformis P.H. Davis (Asteraceae)'den daha önce izole edilmiş olan 11 bileşiğin 2,2-difenil-1-pikrilhidrazil (DPPH) ve ABTS dekolorizasyon yöntemleri ile antioksidan aktivitelerinin incelenmesidir. Bu bileşikler 2 fenolik glikozit (taçiozit ve protokateşik asit), 2 asetofenon glikozidi (pisein ve 4-hidroksiasetofenon 4-O-[6'-O-?-D-apiofuranosil]-?-D-glukopiranozit), 1 kumarin glikozidi (skopolin), 4 flavonoit glikozidi (visenin-2, şaftozit, neoşaftozit ve krizoeriyol-7-Orutinozit), 1 fenilpropanoit glikozidi (siringin) ve 1 neolignan glukozidinden (dihidrodehidrodikoniferil alkol 4-O-?-D-glukopiranozit) oluşmaktadır. Taçiozit ve protokateşik asit her 2 metotta da en yüksek aktiviteye sahiptir (DPPH IC50: 6.47 ve 22.87 mM; TEAC: 33.2±0.18 ve 31.2±0.99, sırasıyla). Dihidrodehidrodikoniferil alkol 4-O-?-D-glukopiranozit de DPPH yönteminde askorbik asit ile karşılaştırıldığında yüksek aktivite göstermiştir (IC50: 27.7 mM). Sonuçlarımız, C. ensiformis'in doğal kaynaklı bir antioksidan kaynağı olma potansiyelini ortaya koymaktadır
The aim of the present study was to investigate the antioxidant activities of 11 phenolic compounds previously isolated from an endemic Centaurea ensiformis P.H. Davis (Asteraceae) by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS decolorization assays. These compounds consisting of 2 phenolic glycosides (tacioside and protocatechuic acid), 2 acetophenon glycosides (picein and 4-hydroxyacetophenon 4-O-[6’O-?-D-apiofuranosyl]-?-D-glucopyranoside), 1 coumarin glucoside (scopolin), 4 flavonoid glycosides (vicenin-2, schaftoside, neoschaftoside and chrysoeriol-7-O-rutinoside), 1 phenylpropanoid glycoside (syringin) and 1 neolignan glucoside (dihydrodehydrodiconiferyl alcohol 4-O-?-D-glucopyranoside). Protocatechuic acid and tachioside had the highest activity (DPPH IC50: 6.47 and 22.87 mM; TEAC: 33.2±0.18 and 31.2±0.99, respectively) in both methods. Dihydrodehydrodiconiferyl alcohol 4-O-?-D-glucopyranoside also showed high activity compared to ascorbic acid in DPPH assay (IC50: 27.7 mM). Our results concluded that the C. ensiformis have a potential source of antioxidants of natural origin
The aim of the present study was to investigate the antioxidant activities of 11 phenolic compounds previously isolated from an endemic Centaurea ensiformis P.H. Davis (Asteraceae) by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS decolorization assays. These compounds consisting of 2 phenolic glycosides (tacioside and protocatechuic acid), 2 acetophenon glycosides (picein and 4-hydroxyacetophenon 4-O-[6’O-?-D-apiofuranosyl]-?-D-glucopyranoside), 1 coumarin glucoside (scopolin), 4 flavonoid glycosides (vicenin-2, schaftoside, neoschaftoside and chrysoeriol-7-O-rutinoside), 1 phenylpropanoid glycoside (syringin) and 1 neolignan glucoside (dihydrodehydrodiconiferyl alcohol 4-O-?-D-glucopyranoside). Protocatechuic acid and tachioside had the highest activity (DPPH IC50: 6.47 and 22.87 mM; TEAC: 33.2±0.18 and 31.2±0.99, respectively) in both methods. Dihydrodehydrodiconiferyl alcohol 4-O-?-D-glucopyranoside also showed high activity compared to ascorbic acid in DPPH assay (IC50: 27.7 mM). Our results concluded that the C. ensiformis have a potential source of antioxidants of natural origin
Açıklama
Anahtar Kelimeler
Farmakoloji ve Eczacılık
Kaynak
Turkish Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
1
