Age related differences in plasma theophylline levels
Küçük Resim Yok
Tarih
1994
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer-Verlag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Because of its special pharmacokinetic properties, plasma levels of theophylline show significant differences between individuals and also its therapeutic index is very low. So, plasma theophylline concentration measurements are essential for an effective and safe treatment. In the present sutyd, age related differences in plasma theophylline levels were evaluated in patients from different age groups. Patients were divided randomly into two groups. Group I included patients under the age of 50 years, group II included patients over 50 years of age. Plasma theopylline levels were measured before and 3, 7, 12 and 19 h after a single dose given orally. The results show that 3, 7 and 19 h post dose, levels of theophylline were significantly higher in group II than in group I (P<0.001). © 1994 Springer-Verlag.
Açıklama
Anahtar Kelimeler
age, pharmacokinetics, plasma level, Theophylline
Kaynak
European Journal of Drug Metabolism and Pharmacokinetics
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
19
Sayı
1
