Risk Factors for Erythrocytosis in Renal Transplantation: Is Ganciclovir Therapy One of Them?
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Scientific Information, Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The purpose of this study was to identify the prevalence and risk factors of post-transplant erythrocytosis (PTE) and its relationship with cytomegalovirus (CMV). Material/Methods: The study consisted of patients who received a kidney allograft and followed-up in our nephrology transplantation clinic from 2000 to 2014. Patient age, sex, length of dialysis, etiology of end-stage kidney disease, date of transplantation, medications, types of donors, the development of PTE were recorded. Results: Among 185 adult kidney recipients, 43 (23.2%) had PTE. The average time between transplantation and diagnosis was 36 months. PTE was more common in male patients (P < 0.05) and patients with living donors and those who had been treated with ganciclovir after transplantation (P < 0.05). There were 79 patients treated for CMV - 54 in the non-PTE group and 24 in the PTE group. There was no significant difference in patient age, eti-ology of end-stage kidney disease, and immunosuppressive therapy when comparing the PTE group and non-PTE group. Univariate analysis showed ganciclovir therapy was significantly associated with PTE. However, this was not seen in the multivariate analyses. Conclusions: Treatment with ganciclovir can precipitate development of PTE. Prospective studies are needed to assess the association of between PTE and CMV infection, valganciclovir, and ganciclovir.
Açıklama
Anahtar Kelimeler
Cytomegalovirus, Ganciclovir, Kidney Transplantation, Polycythemia, Risk Factors, Cytomegalovirus-Infection, Posttransplant Erythrocytosis, State, Care
Kaynak
Annals of Transplantation
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
27
