Identification of axonal involvement in Hallervorden-Spatz disease with magnetic resonance spectroscopy
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Masson Editeur
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Hallervorden-Spatz disease is a neurodegenerative disorder associated with cysteine-iron complex accumulation typically seen as bilateral symmetrical hypointense signal changes in the medial globus pallidus on magnetic resonance imaging. We used magnetic resonance spectroscopy to identify and quantify neuronal damage in two siblings with Hallervorden-Spatz disease. The first patient presenting with a rapidly progressive extrapyramidal syndrome had markedly decreased Nacetylaspartate (NAA) to creatinine (Cr) ratios in the globus pallidi and the periatrial white matter. He also had increased myoinositol (ml) to creatinine (Cr) ratios implying glial proliferation in the affected regions. However the second patient who had the initial presentation of disease had normal NAA/Cr and ml/Cr ratios. These findings indicate that the quantification of NAA:Cr and ml:Cr ratios might be used to predict the extent of neuronal axonal loss and glial proliferation in patients with Hallervorden-Spatz disease respectively.
Açıklama
Anahtar Kelimeler
Hallervorden-Spatz syndrome, neurodegenerative diseases, magnetic resonance imaging, magnetic resonance spectroscopy
Kaynak
Journal of Neuroradiology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
33
Sayı
2
