Do plasma ferritin, C-reactive protein or alpha-fetoprotein predict pregnancy outcome in women with preterm premature rupture of membranes?
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Tarih
2001
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info:eu-repo/semantics/openAccess
Özet
Amaç: Bu prospektif kontrollü çalışmanın amacı 20-36. gebelik haftalarında preterm prematür membran rüptürü olan gebelerde plazma ferritin, C-reaktif protein ve alfa-fetoprotein düzeylerinin maternal ve neonatal sonuçlarla ilişkisini saptamaktır. Gereç ve Yöntem: 20 ile 36. gebelik haftaları arasında preterm prematür membran rüptürü saptanan 43 gebenin plazma ferritin, C-reaktif protein ve alfa-fetoprotein düzeyleri ile 20-36 haftalık sağlıklı gebeliği olan 45 hastanın düzeyleri karşılaştırılmıştır. Sonuçlar koriyoamnionit varlığı, doğuma kadar olan latent periyod, neonatal sepsis ve ölüm açısından karşılaştırılmıştır. Bulgular: Çalışma grubunda C-reaktif protein ve ferritin düzeyleri kontrol grubuna göre anlamlı düzeyde yüksek bulundu (sırasıyla, 1.28±1.9 mg/dL ve 0.51±0.33 mg/dL, p=0.01 ile 25.6±20.1 ng/mL ve 11.2±5.9 ng/mL, p=0.001). Plazma ferritin düzeyleri ile latent periyod arasında pozitif korelasyon saptandı(r=0.32, p=0.03). İlk yatıştaki ve doğum sırasındaki alfa- f etoprotein düzeyleri ile neonatal sonuçlar arasında negatif korelasyon saptandı(sırasıyla, r=-0.31, p=0.04 ile r=-0.34, p=0.026). Sonuç: C-reaktif protein ve ferritin düzeyleri preterm prematür membran rüptürü olan hastalarda anlamlı olarak daha yüksek olmasına rağmaen, neonatal sonuçlar ile korrelasyon göstermemektedir
OBJECTIVE: The objective of this prospective controlled study was to determine whether plasma ferritin, C-reactive protein or alpha-fetoprotein levels predict maternal or neonatal outcomes in women with preterm premature rupture of membranes at 20-36 weeks' gestation. MATERIAL AND METHODS: Plasma from 43 women with premature rupture of membranes at 20-36 weeks' gestation were analyzed for ferritin, C-reactive protein and alpha-fetoprotein, and the results were compared with 45 women with healthy pregnancy at 20-36 weeks' gestation. The results were also compared with the development of chorioamnionitis, latent period until delivery and neonatal sepsis and death. RESULTS: C-reactive protein and ferritin levels were found to be significantly higher in the study group compared with control group (1.28±1.9 mg/dL versus 0.51±0.33 mg/dL, p=0.01 and 25.6±20.1 ng/mL versus 11.2±5.9 ng/mL, p=0.001, respectively). There was positive correlation between the latent period and the plasma ferritin levels (r=0.32, p=0.03). There was a significant negative correlation between the adverse neonatal outcome and alpha-fetoprotein level both on admission and at delivery (r=-0.31, p=0.04 and r=-0.34, p=0.026, respectively). CONCLUSION: C-reactive protein and ferritin levels are found to be significantly higher in patients with preterm premature rupture of membranes; however, there seems to be no correlation between the adverse neonatal outcome. (Gynecol Obstet Reprod Med 2001; 7:86-89)
OBJECTIVE: The objective of this prospective controlled study was to determine whether plasma ferritin, C-reactive protein or alpha-fetoprotein levels predict maternal or neonatal outcomes in women with preterm premature rupture of membranes at 20-36 weeks' gestation. MATERIAL AND METHODS: Plasma from 43 women with premature rupture of membranes at 20-36 weeks' gestation were analyzed for ferritin, C-reactive protein and alpha-fetoprotein, and the results were compared with 45 women with healthy pregnancy at 20-36 weeks' gestation. The results were also compared with the development of chorioamnionitis, latent period until delivery and neonatal sepsis and death. RESULTS: C-reactive protein and ferritin levels were found to be significantly higher in the study group compared with control group (1.28±1.9 mg/dL versus 0.51±0.33 mg/dL, p=0.01 and 25.6±20.1 ng/mL versus 11.2±5.9 ng/mL, p=0.001, respectively). There was positive correlation between the latent period and the plasma ferritin levels (r=0.32, p=0.03). There was a significant negative correlation between the adverse neonatal outcome and alpha-fetoprotein level both on admission and at delivery (r=-0.31, p=0.04 and r=-0.34, p=0.026, respectively). CONCLUSION: C-reactive protein and ferritin levels are found to be significantly higher in patients with preterm premature rupture of membranes; however, there seems to be no correlation between the adverse neonatal outcome. (Gynecol Obstet Reprod Med 2001; 7:86-89)
Açıklama
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum
Kaynak
GORM:Gynecology Obstetrics & Reproductive Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
2
