İkinci ve erken üçüncü trimester gebeliklerin sonlandırılmasında etkin bir misoprostol kullanım protokolü
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AMAÇ: İkinci ve erken üçüncü trimester gebeliklerin Sonlandırılmasmda Misoprostol'ün intravajinal, intraservikal ve peroral kombine kullanımının etkinliğini ve güvenirliliğini araştırmak. GEREÇ VE YÖNTEM: Çeşitli nedenlerle gebeliğin erken sonlandırılmasına karar verilen 25 gebe kliniğimize kabul edilerek çalışma kapsamına alındı. Olguların gestasyonel yaşları 12-28. gebelik haftaları arasında değişmekteydi. Olgulara 200 mikrogram misoprostol tabletin yarısı intravajinal arka fornikse, yarısı intraservikal, spekulum takıldıktan sonra uzun bir pens yardımıyla, uygulandı. Aynı anda toplam doz 800 mikrogram olacak şekilde peroral 200 mikrogram tablet 2 saatte bir verildi. Sistemik ve pelvik muayene bulguları, laboratuar sonuçları ve yan etkileri takip edildi. BULGULAR: intravajinal ve intraservikal Misoprostol uygulaması ile 12. saatte % 64; 24. saatte % 80; 48. saatte ise tüm olgularda başarıya ulaşıldı. Tüm olgulardaki işlem-sonuç süresi ortalaması 12.6±10.4 saat olarak bulundu. Tedavi kesilmesini gerektirecek düzeyde yan etki gelişmedi. SONUÇ: İkinci ve üçüncü trimester ölü veya malformasyonlu gebeliklerin Sonlandırılmasında Misoprostol'ün intravajinal, intraservikal ve peroral kombine kullanımının etkili ve güvenli bir teknik olduğu saptandı.
OBJECTIVE: To evaluate the efficacy of intravaginal Misoprostol in termination of second and early third trimester pregnancies. MATERIALS AND METHOD: Twenty five pregnant women whose pregnancies were planned to be terminated were admitted to the study. Their gestational ages were between 12 and 28 weeks. Half of the 200 micrograms Misoprostol tablet was administered intravaginally to the posterior fornix and the other half intracervically after speculum administration via a long instrument. In addition a dose of 200 micrograms of Misoprostol was administered perorally in every 2 hours to reach a total dose of 800 micrograms. Systemic and pelvic examination findings, laboratory results and side effects were noted. RESULTS: The success rate after the administration of intravaginal and intracervical Misoprostol was 64 % within 12 hours; 80 % within 24 hours and 100 % within 48 hours. The mean interval from administration to termination was 12.6±10.4 hours. The side effects were insignificant in regard of terminating the therapy. CONCLUSION: Intravaginally and intracervically administration of Misoprostol in terminating second and early third trimester pregnancies has the potential to provide efficient and safe results in the dosages used.
OBJECTIVE: To evaluate the efficacy of intravaginal Misoprostol in termination of second and early third trimester pregnancies. MATERIALS AND METHOD: Twenty five pregnant women whose pregnancies were planned to be terminated were admitted to the study. Their gestational ages were between 12 and 28 weeks. Half of the 200 micrograms Misoprostol tablet was administered intravaginally to the posterior fornix and the other half intracervically after speculum administration via a long instrument. In addition a dose of 200 micrograms of Misoprostol was administered perorally in every 2 hours to reach a total dose of 800 micrograms. Systemic and pelvic examination findings, laboratory results and side effects were noted. RESULTS: The success rate after the administration of intravaginal and intracervical Misoprostol was 64 % within 12 hours; 80 % within 24 hours and 100 % within 48 hours. The mean interval from administration to termination was 12.6±10.4 hours. The side effects were insignificant in regard of terminating the therapy. CONCLUSION: Intravaginally and intracervically administration of Misoprostol in terminating second and early third trimester pregnancies has the potential to provide efficient and safe results in the dosages used.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Medical Network Klinik Bilimler ve Doktor
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
1
