Diffusion MRI findings in Wilson's disease
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Six patients having Wilson's disease were studied with diffusion MRI in order to characterize cerebral lesions. Diffusion MRI was obtained using the spin-echo, echo-planar sequence with a gradient strength of 30 mT/m. The trace protocol was used in the axial imaging plane. Heavily diffusion-weighted (b = 1000 s/mm(2)) images, and the ADC (apparent diffusion coefficient) values from automatically generated ADC maps were studied. The ADC values of the normal brain parenchyma were available in 17 age-matched cases for comparison (ADC values, 0.85 +/- 0.11 x 10(-3) mm(2)/s). In Wilson's disease two distinct diffusion MRI patterns were observed by quantitative evaluations of the ADC maps; cytotoxic edema-like (ADC values, 0.52 +/- 0.03 x 10(-3) mm(2)/s), and vasogenic edema-like (ADC values, 1.42 +/- 0.17 x 10(-3) mm(2)/s) patterns. Diffusion imaging appears to be a promising sequence to evaluate the changes in the brain tissue in Wilson's disease at least by revealing two different patterns. (C) 2002 Elsevier Science Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Wilson's disease, brain, diffusion-weighted MRI
Kaynak
Computerized Medical Imaging and Graphics
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
27
Sayı
1
