Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats

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dc.contributor.authorYusufoglu, Hasan S.
dc.contributor.authorSoliman, Gamal A.
dc.contributor.authorAbdel-Rahman, Rehab F.
dc.contributor.authorAbdel-Kader, Maged Saad
dc.contributor.authorGenaie, Majid A.
dc.contributor.authorBedir, Erdal
dc.contributor.authorErel, Sura Baykan
dc.contributor.authorOzturk, Bintug
dc.date.accessioned2019-10-27T22:12:15Z
dc.date.available2019-10-27T22:12:15Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to estimate the potential in vitro antioxidant effect of the methanol extracts of Ferula drudeana Korovin (F. drudeana) and Ferula huber-morathii Pesmen (F. huber-morathii). The antidiabetic activity of both extracts was evaluated in streptozotocin (STZ)-induced diabetic rats. Glibenclamide was taken as the standard drug. Both extracts showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant assay. Oral administration of F. drudeana (400 mg kg(-1)) and F. huber-morathii (200 and 400 mg kg(-1)) extracts to diabetic rats produced a marked reduction in Fasting Blood Glucose (FBG) and elevation in insulin levels after 14 and 28 days of treatment. A meaningful reduction in the concentrations of glycosylated hemoglobin (HbA1c), triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein (LDL) in plasma and elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals medicated with F. drudeana (200 and 400 mg kg(-1)) and F. huber-morathii (400 mg kg(-1)) extracts. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. drudeana and F. huber-morathii-medicated diabetic rats. Besides, biochemical results were supported by histopathological findings. These findings showed the significant antioxidant and hypoglycemic activities of F. drudeana and F. huber-morathii extracts in diabetic rats.en_US
dc.description.sponsorshipDeanship of Scientific Research, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA [2014/01/787]en_US
dc.description.sponsorshipThis work was supported by Research Projects with Global Partnership Program, Deanship of Scientific Research, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA. Grant No. 2014/01/787. The authors would like to express their gratitude to the Deanship of Scientific Research, Prince Sattam bin Abdulaziz University Al-Kharj, for their assistance.en_US
dc.identifier.doi10.3923/ijp.2015.738.748
dc.identifier.endpage748en_US
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issn1811-7775en_US
dc.identifier.issn1812-5700en_US
dc.identifier.issue7en_US
dc.identifier.startpage738en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2015.738.748
dc.identifier.urihttps://hdl.handle.net/11454/49311
dc.identifier.volume11en_US
dc.identifier.wosWOS:000369214200012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApiaceaeen_US
dc.subjectdiabetesen_US
dc.subjectstreptozotocinen_US
dc.subjectDPPHen_US
dc.subjectinsulinen_US
dc.subjectblood glucoseen_US
dc.titleAntioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Ratsen_US
dc.typeArticleen_US

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