Insulin resistance in children with familia hyperlipidemia
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The aim of the study was to investigate whether there is insulin resistance in children with familial hyperlipidemia (FHL) and to determine the factors affecting insulin resistance. Methods: Hyperlipidemic children aged between 4 and 18 years and followed up with an FHL diagnosis were included in the study. The children of adults followed up with an FHL diagnosis were also recruited after the screening period. The scanned children were divided into two groups as hyperlipidemic and normolipidemic. A total of 77 patients of whom 52 were hyperlipidemic and 25 were normolipidemic were assessed in the study. Insulin resistance was evaluated (homeostatic model assessment of insulin resistance [HOMA-IR]) by performing the oral glucose tolerance test (OGTT). Results: Of the patients, 36 were male and 41 were female; the average age was 11.6 +/- 3.9 years, and the body mass index (BMI) was established to be 20.3 +/- 4.4. In hyperlipidemic and normolipidemic patients, the following were determined: fasting insulin: 10.6 (+/- 0.89) mu U/mL, 4.9 (+/- 0.45) mu U/mL (p = 0.000); 2-h insulin: 28.7 (+/- 12.7) mu U/mL 18.9 (+/- 10.5) mu U/mL (p= 0.000); and HOMA-IR: 1.9 (+/- 0.17), 0.86 (+/- 0.7) (p= 0.000). No relationship was identified between lipid profiles and insulin resistance. Nevertheless, there was a positive correlation between insulin resistance and apolipoprotein B (Apo B) levels (0.52), and a negative correlation was determined in carnitine levels (-0.64). Conclusions: Insulin resistance was established to be higher in children with FHL compared to normolipidemic children. Insulin resistance was not related to lipid phenotypes, but to Apo B levels and carnitine levels. Insulin resistance should be a routine method of evaluation in the follow-up of children with FHL.
Açıklama
Anahtar Kelimeler
children, familial hyperlipidemia, insulin resistance
Kaynak
Journal of Pediatric Endocrinology & Metabolism
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
31
Sayı
12
