İleri yaş gebeliklerde amniyosenteze yaklaşım
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Merkezimizdeki beş yıllık amniyosentez verilerinden yola çıkarak endikasyonlara ve yaşa göre anomali dağılımını incelemek. İleri yaş gebeliklerde amniyosenteze yaklaşımı irdelemek. Gereç ve Yöntem: 2008-2012 tarihleri arasında amniyosentez uygulanmış 307 olgu retrospektif değerlendirildi. Endikasyonlar; ileri maternal yaş, tarama testinde risk artışı, ileri maternal yaş ve tarama testinde risk artışı, anormal ultrason bulguları ve diğerleri şeklinde sınıflandı. Sitogenetik bulgular, normal ve anormal olarak sınıflandı. Normal varyasyonlar, normal grubunda değerlendirildi. Anne yaşı ayrıca 35 yaş altı ve 35 yaş ve üstü olarak sınıflandı. Anormal karyotip sonuçları ile endikasyon ve yaş arasındadaki ilişki ki- kare testi ile incelendi. Bulgular: Tarama testinde risk artışı( %37.8), ileri maternal yaş (%32.6), ileri maternal yaş ve tarama testinde risk artışı (%20.8) izlenen endikasyonlardı. Dört olguda kültürde üreme olmadı. Değerlendirmeye alınan 303 olgunun 26 sında (%8.5) anormal karyotip tespit edildi. Otuzbeş yaş altı ve üstünde anomali sıklığı; ve endikasyonlara göre kromozom anomalisi yakalama oranları benzerdi. Ancak, ileri maternal yaş ve tarama testinde risk artışı olan grupta trizomi 21 yakalama oranının daha fazla olduğu görüldü. Sonuç: İleri yaş gebeliklerde amniyosentez kararı verirken; biyokimyasal tanı yöntemleri ve ultrasonografinin kullanılması, anomali yakalama oranını artıracaktır. Hastalar bu konuda yeterli aydınlatılmalı ve karar verirken tıbbın tüm olanakları kullanılmalıdır.
Aim: To determine the rates of amniocentesis indications and karyotype results of the five-year data in our center and to evaluate the approach to amniocentesis in pregnancies with advanced age. Material and Method: Between 2008 and 2012, 307 cases of amniocentesis were evaluated retrospectively. Indications were classified as advanced maternal age, increased risk on screening test, advanced maternal age with increased risk on screening test, abnormal ultrasound findings, and others. Cytogenetic findings were classified as normal and abnormal. Maternal age was also classified as older than 35 years old and others. the relation of abnormal karyotype with indications and age was analyzed by chi-square test. Results: Increased risk on screening test (37.8%), advanced maternal age (32.6%), advanced maternal age and the positive screening test (20.8%) were the indications. Cell culture was not successful in 4 cases. Abnormal karyotype was detected in the 26(8.5%) of 303 patients. the frequency of anomalies was not different in terms of the maternal age and the indications. However, in the group with advanced maternal age and increased risk screening test, the detection rate of trisomy 21 was higher. Conclusion: in the course of amniocentesis decision in advanced age pregnancies; the use of ultrasound and biochemical diagnostic methods increases the potential for detection of anomaly. Patients should be illuminated enough about it, and all the facilities of medicine should be used when deciding on the indication.
Aim: To determine the rates of amniocentesis indications and karyotype results of the five-year data in our center and to evaluate the approach to amniocentesis in pregnancies with advanced age. Material and Method: Between 2008 and 2012, 307 cases of amniocentesis were evaluated retrospectively. Indications were classified as advanced maternal age, increased risk on screening test, advanced maternal age with increased risk on screening test, abnormal ultrasound findings, and others. Cytogenetic findings were classified as normal and abnormal. Maternal age was also classified as older than 35 years old and others. the relation of abnormal karyotype with indications and age was analyzed by chi-square test. Results: Increased risk on screening test (37.8%), advanced maternal age (32.6%), advanced maternal age and the positive screening test (20.8%) were the indications. Cell culture was not successful in 4 cases. Abnormal karyotype was detected in the 26(8.5%) of 303 patients. the frequency of anomalies was not different in terms of the maternal age and the indications. However, in the group with advanced maternal age and increased risk screening test, the detection rate of trisomy 21 was higher. Conclusion: in the course of amniocentesis decision in advanced age pregnancies; the use of ultrasound and biochemical diagnostic methods increases the potential for detection of anomaly. Patients should be illuminated enough about it, and all the facilities of medicine should be used when deciding on the indication.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Van Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
3
