Humoral immune responses against Plasmodium Civax MSP1 in humans living in a malaria endemic area in flores, Indonesia
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Tarih
1998
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to evaluate the relationship among age, parasitemia status, spleen size, hematocrit, and antibody levels to Plasmodium vivax merozoite surface protein 1 (MSP 1 ) in individuals chronically exposed to P. vivax. Subjects were recruited from the population of three adjacent villages on the Island of Flores in Indonesia where malaria transmission is hyperendemic and tropical splenomegaly syndrome is highly prevalent. Subjects were evaluated for spleen size, hematocrit, presence of parasitemia, and presence of antibodies to a recombinant peptide consisting of 90 amino acids from the carboxy terminus of MSP1. Fifty-seven percent of 2-4 year olds, 45% of 5-9 years old, and 7% of ? 15 years old were parasitemic; 99% of the ? 15 years old had splenomegaly, and 31% of them had Hackett 4 or 5 spleens. The frequency of antibody positivity to MSP1 antigen in ELISA increased with age reaching a maximum of 89% in ? 20 years old. The frequency of antibody positivity to MSP1 also increased with spleen size, and with a decline in the prevalence of parasitemia.
Açıklama
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Kaynak
Southeast Asian Journal of Tropical Medicine and Public Health
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
29
Sayı
4
