The relation of adiponectin and tumor necrosis factor ? levels between endothelial nitric oxide synthase, angiotensin-converting enzyme, transforming growth factor ß, and tumor necrosis factor ? gene polymorphism in adrenal incidentalomas
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of our study was to demonstrate demographic characteristics, presence of inflammatory markers, distribution of angiotensin-converting enzyme (ACE), tumor necrosis factor (TNF), endothelial nitric oxide synthase (eNOS) genotypes and relations among these parameters in these patients and control subjects. Research design and methods: Study samples were collected from 50 patients with adrenal mass and 30 control groups. The eNOS, ACE, TNF-?, transforming growth factor (TGF)-ß genes polymorphisms, TNF-?, adiponectin levels were analysed in 50 unrelated Turkish patients with a diagnosis of adrenal incidentaloma (Al). Results: There was statistically significant difference between TNF-? levels of patient and controls (p=0.048). We have not detected the connection between TGF-ß, TNF-?, ACE, eNOS gene polymorphism with serum TNF-? and adiponectin levels. In this study, we demonstrated that there were significant differences for ACE genotypes in the patients when compared to the controls (p<0.05). The percentages of the ID, DD, II genotypes for ACE gene polymorphism in the patients group were 30.0, 13.0, 7.0%, respectively. Conclusions: According to different cases of eNOS, TGF-ß, ACE, and TNF-? gene genotypes; no statistical significant difference was found between basal Cortisol, ACTH, DHEAS, metanephrine, renin, aldosterone, normetanephrine, 17- hydroxyprogesterone, 1 mg low-dose dexamethasone suppression test-cortisol response and Al size. In this study, I/D genotype was determined to be statistically higher in ACE gene in patients with Al (p=0.014). ©2009, Editrice Kurtis.
Açıklama
Anahtar Kelimeler
ACE, Adiponectin, Adrenal incidentalomas, eNOS, TGF-ß, TNF-? gene polymorphism, TNF-? levels
Kaynak
Journal of Endocrinological Investigation
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
32
Sayı
11
