Cyclic voltammetry of echinomycin and its interaction with double-stranded and single-stranded DNA adsorbed at the electrode
Küçük Resim Yok
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Sa
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Interactions of echinomycin (Echi) with DNA was studied by cyclic voltammetry (CV) with hanging mercury drop electrode (HMDE). Echinomycin was electrochemically active, yielding several signals. Interaction of Echi with dsDNA attached to a hanging mercury drop electrode resulted in high Echi signals, suggesting a strong binding of Echi to dsDNA by bis-intercalation at the electrode surface. Under the same conditions, interaction of Echi with ssDNA produced almost no Echi signal. This behavior is in agreement with a strong binding of Echi to dsDNA and a very weak binding of Echi to ssDNA observed earlier in solution. Echi, thus, appears to be a good candidate for redox indicator in electrochemical DNA hybridization sensors. (C) 2002 Elsevier Science B.V. All rights reserved.
Açıklama
26th International Symposium on Bioelectrochemistry and Bioenergetics -- 2001 -- BRATISLAVA, SLOVAKIA
Anahtar Kelimeler
electrochemistry of DNA, interaction of DNA with echinomycin, hanging mercury drop electrode, DNA hybridization sensors, DNA bis-intercalator
Kaynak
Bioelectrochemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
55
Sayı
01.Feb
