Prognostic Value of Cardiopulmonary Exercise Test Parameters in Ventricular Assist Device Therapy
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cardiopulmonary exercise test (CPET) parameters are established prognosticators in heart failure. However, the prognostic value of preimplantation and postimplantation CPET parameters in left ventricular assist device (LVAD) therapy is unclear and it is evaluated in this study. Adult patients who were implanted with an LVAD and underwent CPET during the preimplantation or postimplantation period were retrospectively analyzed. Five CPET parameters were calculated: vO(2) max, oxygen uptake efficiency slope (OUES), VE/vCO(2) Slope, VE/vCO(2) min, and VE/vCO(2) max. The relationship between CPET parameters and postimplantation outcomes was evaluated with multivariable analysis. Pre and postimplantation CPET cohorts included 191 and 122 patients, respectively. Among preimplantation CPET parameters: vO(2) max and OUES were associated with 1, 3, and 5 year mortality, VE/vCO(2) min was associated with 3 and 5 year mortality, whereas VE/vCO(2) Slope was associated with 5 year mortality. From postimplantation CPET parameters: vO(2) max was an independent predictor of 3 and 5 year mortality, whereas VE/vCO(2) max was an independent predictor of 3 year mortality following LVAD implantation. Preimplantation CPET parameters have a prognostic value for long-term survival following LVAD implantation, whereas their association with early postimplantation outcomes appears to be weaker. Postimplantation vO(2) max and VE/vCO(2) max values are associated with survival on device support and may provide a second chance for prognostication in patients without preimplantation CPET data.
Açıklama
Anahtar Kelimeler
LVAD, ventricular assist device, mechanical circulatory support, cardiopulmonary exercise test, vO(2) max, oxygen consumption, VE, vCO(2) slope, ventilatory efficiency, prognosis, risk stratification, Heart-Failure Patients, Increasing Pump Speed, Oxygen-Uptake, Flow, Support, Hemodynamics, Ventilation
Kaynak
Asaio Journal
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
68
Sayı
6
