Retrospective evaluation of the short-term effectiveness of non-enzymatically isolated stromal vascular fraction cells in patients with knee osteoarthritis

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dc.contributor.authorSafarli A.
dc.contributor.authorKirnaz B.
dc.contributor.authorKumcuoglu D.
dc.contributor.authorMahmudov V.
dc.contributor.authorKarimov Z.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-08-31T07:42:34Z
dc.date.available2024-08-31T07:42:34Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Knee osteoarthritis (KOA) is the most common degenerative joint disease. Adipose-derived stromal vascular fraction cell therapy slows the progression of knee osteoarthritis and prevents hyaline cartilage degeneration without serious side effects. This study aims to present retrospectively the effectiveness of stromal vascular fraction cells isolated from adipose tissue by the non-enzymatic method applied to 55 osteoarthritis patients of different age groups and Kellgren-Lawrence grades on the recovery of the disease. Material and Methods: Fifty-five patients with knee osteoarthritis, treated with stromal vascular fraction cells at the International Medical Centre (Azerbaijan) between 2020 and 2021, were included in the study to be evaluated retrospectively. Patients aged 32–67 years, Grades I–IV according to Kellgren-Lawrence classification, were included in this study. Pain and functional limitations were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaires before treatment, at the 5th month, and 12th month after stromal vascular fraction injection. Results: At the fifth and 12th months post-treatment, it was observed that the WOMAC scores were significantly improved compared with pre-treatment scores. It was also observed that stromal vascular fraction therapy was effective for Kellgren-Lawrence Grades I and II at 12 months. The most significant decrease in the WOMAC score after stromal vascular fraction treatment was observed in patients aged 45–60 years, and it was also found that there was no meaningful relationship between stromal vascular fraction efficiency and gender. Conclusion: According to our results, non-enzymatically stromal vascular fraction treatment is more effective for longer in osteoarthritis patients with early age and low Kellgren-Lawrence grades (I and II). Moreover, our finding is that the stromal vascular fraction cells could be used safely in osteoarthritis treatments and significantly benefit patients’ quality of life. © The Author(s) 2024.en_US
dc.identifier.doi10.1177/22104917241258237
dc.identifier.issn2210-4917
dc.identifier.scopus2-s2.0-85199763165en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org10.1177/22104917241258237
dc.identifier.urihttps://hdl.handle.net/11454/103941
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofJournal of Orthopaedics, Trauma and Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectKnee osteoarthritisen_US
dc.subjectnon-enzymatic isolationen_US
dc.subjectregenerationen_US
dc.subjectstromal vascular fraction therapyen_US
dc.titleRetrospective evaluation of the short-term effectiveness of non-enzymatically isolated stromal vascular fraction cells in patients with knee osteoarthritisen_US
dc.typeArticleen_US

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