Role of microbiota and microbiota-derived short-chain fatty acids in PDAC
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome-derived short-chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short-chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.
Açıklama
Anahtar Kelimeler
host-microbe interactions, inflammation, microbiome, microbiota, pancreatic ductal adenocarcinoma, SCFA, Pancreatic Ductal Adenocarcinoma, Kappa-B Activation, Sodium-Butyrate, Gut Microbiota, Tumor Microbiome, Bacterial Translocation, Intestinal Microbiota, Colonic Inflammation, Metabolite Butyrate, Helicobacter-Pylori
Kaynak
Cancer Medicine
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
