Progressive Transformation of Germinal Centers: Single-Center Experience of 33 Turkish Patients
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cig Media Group, Lp
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We reviewed the records of patients with progressive transformation of germinal centers (PTGCs) to determine the clinicopathologic features and association with any type of lymphoma. We determined that PTGCs can be seen simultaneously with lymphoma and during the follow-up of patients with lymphoma. Progressive transformation of germinal centers (PTGCs) is a benign disease of the lymph nodes that is rarely associated with Hodgkin disease. We reviewed the clinical and pathologic features of PTGCs and the relationship of PTGCs with lymphoid neoplasia in an adult population. The data from 33 patients who were diagnosed with PTCGs were retrospectively analyzed. Of the 33 PTGC patients, 48.5% were men and 51.5% were women, with a mean age of 43.8 years at diagnosis. Most of the enlarged and excised lymph nodes were cervical and axillary. Diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma was detected concurrent with PTGC in 2 patients. Also, PTGCs was detected 3 years after the diagnosis of diffuse large B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and T-cell-rich B-cell lymphoma in 3 patients. No relapse was found in the patients with lymphoma, and no progression to lymphoma was detected during the follow-up of the other patients. PTGCs is not considered a premalignant entity; however, the development of lymphoma has been reported rarely. If PTGCs occurs in the follow-up process of patients with lymphoma, the follow-up intervals should be shortened. (C) 2016 Elsevier Inc. All rights reserved.
Açıklama
3rd Annual Meeting of the Society-of-Hematologic-Oncology (SOHO) -- SEP 16-19, 2015 -- Houston, TX
Anahtar Kelimeler
Histopathology, Hodgkin lymphoma, Immunohistology, Lymphanedopathy, Non-Hodgkin lymphoma
Kaynak
Clinical Lymphoma Myeloma & Leukemia
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
16
