Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of Tc-99m and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (Tc-99m-AZA-SLMNP) was investigated in vitro and in vivo.
Açıklama
Anahtar Kelimeler
Azathioprine, Solid lipid nanoparticles, Magnetic nanoparticles, Radiolabeling, In vitro, In vivo, Delivery
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
