The effect of inhaled corticosteroids on bronchoalveolar lavage cells and IL-8 levels in stable COPD patients
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Chronic obstructive pulmonary disease (COPD) is characterised by a chronic inflammatory process in the large and small airways, as well as in the lung parenchyma. Although the rote of oral corticosteroids in the management of acute exacerbations of COPD is well documented, its rote in stable COPD is not clear. We examined the anti-inflammatory effect of inhaled budesonide on the percentage of neutrophils and on interleukin-8 (IL-8) levels in bronchoalveolar lavage (BAL) and their correlation with spirometry and symptom scores. Twenty-six patients with stable COPD were randomised, in a double-blinded, placebo-controlled trial with either 800 mu g of inhaled budesonide or placebo for a 6-month period. The budesonide-treated subjects had significant reductions in IL-8 levels in the BAL after therapy (mean +/- SEM, 1.53 +/- 0.72 at baseline vs. 0.70 +/- 0.48 ng/ml at 6 months, P = 0.004) and a reduction in the mean percentages of neutrophils (17.16 +/- 2.67% vs. 13.25 +/- 2.28% P = 0.002). The improvement in sputum production was of borderline (P = 0.058) significance but there was no improvement in lung function. In stable patients with COPD, treatment with inhaled budesonide for a period of 6 months has a positive effect on markers of lung inflammation, as assessed by reduction in percentage neutrophils and IL-8 concentration in BAL. (c) 2005 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
COPD, interleukin-8, bronchoalveolar lavage, inhaled, steroids, budesonide
Kaynak
Respiratory Medicine
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
99
Sayı
12
