Regulation of ER-associated degradation via p97/VCP-interacting motif
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Portland Press Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
p97/VCP (valosin-containing protein) is a cytosolic AAA (ATPase associated with various cellular activities) essential for retrotiranslocation of misfolded proteins during ERAD [ER (endoplasmic reticulum)-associated degradation]. gp78, an ERAD ubiquitin ligase, is one of the p97/VCP recruitment proteins localized to the ER membrane. A newly identified VIM (p97/VCP-interacting motif) in gp78 has brought about novel insights into mechanisms of ERAD, such as the presence of a p97/VCP-dependent but Ufd1-independent retrotranslocation during gp78-mediated ERAD. Additionally, SVIP (small p97/VCP-interacting protein), which contains a VIM in its N-terminal region, negatively regulates ERAD by uncoupling p97/VCP and Derlin1 from gp78. Thus SVIP may protect cells from damage by extravagant ERAD.
Açıklama
3rd Intracellular Proteolysis Meeting -- MAR 05-07, 2008 -- Canary Isl, SPAIN
Anahtar Kelimeler
endoplasmic reticulum (ER), endoplasmic-reticulum-associated degradation (ERAD), gp78, p97/VCP-interacting matif (VIM), small p97/VCP-interacting protein (SVIP)
Kaynak
Biochemical Society Transactions
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
36
