Biological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
WST-1-based cytotoxicity assay of lawsone (LW) was performed on MCF7, Caco2, BJ and Keratinocyte cells and viabilities were found as over 90 % for all cells. Significant wound healing effect of LW was reported on Keratinocyte cells. Antibacterial and antifungal activities of LW were tested on seven microorganisms with three concentrations and 1,000 A mu g/disc of LW showed antibacterial effect on Bacillus subtilis. In vitro cell incorporation of radioiodinated LW (I-131-LW) was evaluated on same cells. Keratinocyte cells uptake were 5 times more. Consequently, I-131-LW was found usable for researches about especially skin diseases in addition to breast and intestinal cancer.
Açıklama
Anahtar Kelimeler
Lawsonia inermis, Lawsone, I-131, Cell culture, Wound healing, Antibacterial and antifungal activity
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
303
Sayı
1
