Synthesis of alpha-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A new method for converting terminal epoxides and primary alcohols into alpha-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.
Açıklama
Anahtar Kelimeler
Anti-Markovnikov Alcohols, Borrowing Hydrogen, Terminal Epoxides, Regioselective Isomerization, C-C, Catalyst, Rearrangement, Complexes, Methylation, Secondary
Kaynak
Organic Letters
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
23
Sayı
13
